BDD Pharma
The company ’ s range of services cater to the individual needs of each client , whether they are troubleshooting , developing a new formulation or testing a product in vitro ( in the lab ) or in vivo ( inside a human ). In doing so , BDD calls upon its imaging and pharmacokinetic techniques , as well as its knowledge of biopharmaceutics . A key area of the organization ’ s focus is the development of unique , targeted release profiles with oral drug delivery systems . BDD is an expert in utilizing hot melt extrusion , wet and dry granulation and different coatings in the development of innovative drug products . Its partners are spread all over the world and range from small virtual biotechs to large global pharma companies .
Treatment solutions
In discussing BDD ’ s patented release technology , Carol Thomson , Chief Executive Officer , states : “ We developed OralogiK™ as an attractive alternative to diffusion-based matrix release or coated multiparticulate technologies for controlled release . OralogiK™ is neither pH dependent nor reliant on uniform conditions within the Gastrointestinal Tract ( GIT ), whereas issues in the GIT system relating to stasis , variable fluid volumes or motility can have negative consequences for diffusional drug release mechanisms . Our solution is uniquely based on an erosion technology that is not impacted by these factors and this allows us to create complex release profiles that are otherwise unachievable .
“ This erodible layer is compressed around a tablet containing the Active Pharmaceutical Ingredient ( API ), which provides the specific dose . This layer is designed to break down at a consistent rate , independent of its location within the GIT , allowing us to create lag times of up to 12 hours between the dose being taken and the drug entering the patient ’ s system . Its real USP is the way in which it can operate regardless of biological factors such as pH changes , agitation and stomach contents , and doesn ’ t rely on the patient ’ s gut microbiome or enzymatic composition .
“ This technology has been repeatedly tested in the clinical setting and can be tailored specifically to our partners ’ requirements . In an alternative sustained
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